Vaccine Lab / Alfa Chemistry
Sorbitan monopalmitate

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Sorbitan monopalmitate

Catalog Number ACM26266579
CAS 26266-57-9
Structure
Description DryPowder;Light cream to tan-coloured beads or flakes or a hard, waxy solid with a slight characteristic odour
Synonyms Span 40
IUPAC Name [(2R)-2-[(2R,3R,4S)-3,4-Dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate
Molecular Weight 402.6
Molecular Formula C22H42O6
Canonical SMILES CCCCCCCCCCCCCCCC(=O)OCC(C1C(C(CO1)O)O)O
InChI InChI=1S/C22H42O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(25)27-17-19(24)22-21(26)18(23)16-28-22/h18-19,21-24,26H,2-17H2,1H3/t18-,19+,21+,22+/m0/s1
InChI Key IYFATESGLOUGBX-YVNJGZBMSA-N
Melting Point 46-47°C
Flash Point 113°C
Purity 95%+
Density 1.075 g/cm³
Solubility Soluble at temperatures above its melting point in ethanol, methanol, ether, ethyl acetate, aniline, toluene, dioxane, petroleum ether and carbon tetrachloride. Insoluble in cold water but dispersible in warm water
Appearance Cream color flake
Application This product is suitable for scientific research.
Complexity 389
Covalently-Bonded Unit Count 1
Defined Atom Stereocenter Count 4
EC Number 247-568-8
Exact Mass 402.29813906
Heavy Atom Count 28
Hydrogen Bond Acceptor Count 6
Hydrogen Bond Donor Count 3
Isomeric SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H]([C@@H]1[C@@H]([C@H](CO1)O)O)O
MDL Number MFCD00080946
Monoisotopic Mass 402.29813906
NACRES NA.23
Physical State Solid
PubChem ID 24864252
Rotatable Bond Count 18
Topological Polar Surface Area 96.2 Ų
Knowledge & Learning Case Study Q&A

Sorbitan Monopalmitate (SMP) for the Preparation of Calcium Phosphate Composite Castor Oil Based Gels

Castor oil-based gel containing calcium phosphate/sorbitan monopalmitate nanocomposite as proof of concept for tooth sensitivity treatmentAuthor links open overlay panel Thongnasan N, et al. Materials Today: Proceedings, 2023, In Press

Sorbitan monopalmitate (SMP) can be mixed with castor oil to prepare a calcium phosphate composite castor oil-based gel using a water-in-oil emulsion method. The detailed procedure is as follows:
Mixing: Combine 820 µL of castor oil and 0.25 g of SMP in a 10 mL vial. Stir the mixture at 700 rpm while heating to 60°C until a uniform mixture is obtained.
Emulsification: Add 100 µL of calcium chloride dihydrate (CaCl₂·2H₂O, 7.2 M) to the mixture and continue stirring for 30 minutes to form an emulsion.
Reaction: Slowly add 700 µL of disodium hydrogen phosphate (Na₂HPO₄) aqueous solution using a pipette, and continue stirring the mixture for 1 hour to complete the reaction.
Gel Formation: Allow the hot mixture to cool and solidify at room temperature, forming the gel.
This method ensures the formation of a stable calcium phosphate composite gel with castor oil and SMP as the base materials.

Effect of Sorbitan Monopalmitate on the Gelation Process of Ethyl Cellulose

Surfactant addition to modify the structures of ethylcellulose oleogels for higher solubility and stability of curcumin Liu N, et al. International Journal of Biological Macromolecules, 2020, 165(B), 2286-2294.

This case study aims to investigate the effect of the surfactant sorbitan monopalmitate (SMP) on the gelation process of ethyl cellulose (EC). The goal is to enhance curcumin loading by reducing lipid oxidation while also improving the solubility and chemical stability of curcumin.
Morphological Analysis: Samples prepared without SMP exhibited a wide pore size distribution and a highly uneven gel network. Some areas were nearly collapsed due to the connection of large pores. When small amounts of SMP were added, the number of large pores decreased, and this effect became more pronounced with increasing SMP content. Larger pores in the network trapped larger oil droplets, adversely affecting macroscopic properties.
Rheological Properties: Rheological data showed improved viscoelastic properties of the oleogels prepared with SMP. This improvement is likely due to interactions between the surfactant and the polar entities of the EC main chain.
Functional Benefits: The formation of a more compact network had a direct impact on inhibiting the crystallization of curcumin, slowing lipid oxidation, and providing resistance to UV exposure.
The addition of SMP to the EC gelation process significantly improves the structural integrity and functional performance of the oleogels. This enhancement is attributed to the surfactant's ability to reduce pore size and interact with the EC network, resulting in better curcumin loading, increased solubility, and greater chemical stability.

What is the molecular formula of Sorbitan monopalmitate?

The molecular formula of Sorbitan monopalmitate is C22H42O6.

What is the IUPAC name of Sorbitan monopalmitate?

The IUPAC name of Sorbitan monopalmitate is [(2R)-2-[(2R,3R,4S)-3,4-Dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate.

What is another name for Sorbitan monopalmitate?

Another name for Sorbitan monopalmitate is Span 40.

What is the appearance of Sorbitan monopalmitate?

The appearance of Sorbitan monopalmitate is light cream to tan-coloured beads or flakes, or a hard, waxy solid with a slight characteristic odor.

What is the melting point of Sorbitan monopalmitate?

The melting point of Sorbitan monopalmitate is 46-47°C.

In which solvents is Sorbitan monopalmitate soluble?

Sorbitan monopalmitate is soluble in ethanol, methanol, ether, ethyl acetate, aniline, toluene, dioxane, petroleum ether, and carbon tetrachloride.

What is the purity of Sorbitan monopalmitate?

The purity of Sorbitan monopalmitate is 95%+.

What category does Sorbitan monopalmitate belong to?

Sorbitan monopalmitate belongs to the Heterocyclic-1 Ring category.

What is the molecular weight of Sorbitan monopalmitate?

The molecular weight of Sorbitan monopalmitate is 402.6.

What are three features and benefits of Sorbitan monopalmitate?

The three features and benefits of Sorbitan monopalmitate are: 1. High quality products 2. Fast delivery 3. Ability to order additional products (contact for details).

Our products and services are for research use only and cannot be used for any clinical purposes.

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