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| Host | Rabbit |
| Target Type | Viral Protein |
| Conjugate | This product is un-conjugated. |
| Applications | ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB) Recommended dilution: ELISA, 1 µg/mL; ICC, 20 µg/mL; IF, 20 µg/mL; WB, 2-5 µg/mL |
| Specificity | This product is specific for the Spike protein RBD domain of the SARS virus. |
| Isotype | IgG |
| Concentration | 1mg/mL |
| Purification | Protein A, Antigen Affinity |
| Buffer | 0.2 μm filtered solution in PBS |
| Shipping | This product is shipped in dry ice unless customers require otherwise. |
| Storage | This product can be stored at 2-8 °C for one year. This product can be stored at −20 to −80 °C for three years. Please avoid freeze-thaw cycles. |
The spike (S) protein of coronavirus is the main target for the development of vaccines and a potential strategy to counteract viral entry into human cells. The S protein forms a trimer at the protrusion of the virus and consists of two functional subunits: S1 and S2 [1]. The coronavirus spike protein has been shown to be a multifunctional molecular machine that mediates the entry of coronaviruses into host cells. It first binds to a receptor on the host cell surface through via S1 subunit and then fuses viral and host membranes via its S2 subunit [2]. The receptor-binding domain (RBD) in the S protein is the most flexible part of the coronavirus structure. It has the function of enabling coronaviruses to bind to target body receptors (e.g. ACE2 on respiratory epithelial cells) and enter the cell to cause infection. Thus, blocking the interaction between ACE2 and RBD significantly inhibits viral infection.
Figure 1. Realistic three-dimensional illustration of COVID-19 virus structure diagram. The red box labeled part is the spike protein, which is the main structural component of the coronavirus virion.
Since the SARS-CoV-2 pandemic, research into the detection and treatment of Coronavirus has never stopped. Alfa Chemistry is committed to providing customers with a series of antibodies for diagnostics to meet the various needs of customers. If the product you are looking for is not in our catalog, please contact us. We will be happy to provide you with customized synthesis services.
Our products and services are for research use only and cannot be used for any clinical purposes.
Alfa Chemistry is a global leader in the vaccine industry. We have the ability to help our customers meet the challenges of various vaccine development processes. Alfa Chemistry believes that partnerships will change the way the world innovates, bringing new technologies.
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