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CONTACT USAlfa Chemistry is pleased to introduce our bioactive lipid products that have shown potential for application in RNA delivery systems.
Bioactive lipids can be used as components of lipid-based RNA molecule delivery systems, and their incorporation can improve the stability, cellular uptake, endosomal escape, and targeting capabilities of these systems.
Experience the next generation of RNA delivery systems with our bioactive lipid products below to advance your research and development in gene therapy, drug discovery, and precision medicine.
Platelet-activating factor (PAF) and PAF analogs are bioactive lipids that play critical roles in cell signaling and inflammatory regulation.
PAF and PAF analogs act by interacting with specific receptors. These molecules can activate or inhibit PAFR-mediated signaling pathways, providing insights into receptor pharmacology and potential therapeutic targets.
BMP is a multifunctional natural lipid molecule that can be implicated in a variety of cellular signaling processes, including intracellular transport, endocytosis, autophagy, and lysosomal function.
BMPs exhibit structural variation in fatty acid chain length, saturation, and acyl chain composition. This structural diversity enables the study of the effects of lipid composition on membrane properties, organization and protein-lipid interactions.
Figure 1. Adjuvants targeting TLR4, TLR7/8, TLR9, and RIG-I delivered on degradable polymer NPs were combined with the S1 subunit of the spike protein and performed in vivo and in vitro assessment.[1].
Toll-like receptor 4 (TLR-4) agonists are powerful immunomodulatory compounds that selectively activate the TLR-4 signaling pathway, triggering a robust immune response. TLR-4 agonists have shown great promise in immunological research, vaccine development, and as adjuvants to enhance therapeutic efficacy.
Our TLR-4 agonist products provide researchers with reliable tools to study immune responses, study mechanisms of TLR-4 activation, and explore therapeutic applications for a variety of diseases.
Lipid nucleotides are a class of nucleotide analogs that contain a lipid moiety attached to the nucleotide backbone. These lipid modifications enhance the properties and functionality of nucleotides, allowing them to interact with cell membranes, improve cellular uptake and regulate specific cellular processes.
The lipid moiety in lipid nucleotides can vary in structure and include fatty acids, cholesterol, or other lipid derivatives. Attachment of lipids to nucleotides can be achieved through various chemical conjugation strategies, such as phosphoramidite chemistry or solid-phase synthesis.
Our products and services are for research use only and cannot be used for any clinical purposes.
Alfa Chemistry is a global leader in the vaccine industry. We have the ability to help our customers meet the challenges of various vaccine development processes. Alfa Chemistry believes that partnerships will change the way the world innovates, bringing new technologies.
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