Neutral Lipids

Alfa Chemistry is pleased to introduce our neutral lipid products that have shown potential for use in RNA delivery systems.

Neutral lipids, also known as non-polar lipids, are a class of lipids characterized by being uncharged and hydrophilic. Unlike polar lipids (e.g., phospholipids and glycolipids), neutral lipids are hydrophobic and insoluble in water. They play an important role in energy storage, insulation and protection of organisms.

Neutral lipids, particularly certain types of neutral lipid-based delivery systems, have been explored for their potential use in RNA delivery. Although lipid-based delivery systems are primarily composed of polar lipids (e.g., phospholipids), neutral lipids can be incorporated into these systems to enhance their stability and delivery efficiency.

Glycerides for RNA Delivery

Glycerides are a class of glycerol-derived lipids consisting of one or more fatty acid chains esterified with the glycerol backbone that can be modified and used in lipid-based RNA molecular delivery systems.

Figure 1. Schematic representation of mono-, di-, and triacylglycerol and example of a TAG (1-palmitoyl-2-oleoyl-3-stearoyl-sn-glycerol)[1].

The following are some examples:

• Lipid nanoparticles (LNPs) are widely used for RNA delivery and can have glycerides doped into their lipid formulation. Glycerides can be included with other lipid components to form the lipid bilayer of the LNP. These glycerides contribute to the stability, structure, and delivery efficiency of the LNP.
• Solid lipid nanoparticles (SLN), which consist of solid lipids including glycerides, have been used for RNA delivery. Glycerides can be used as solid lipid components in SLN, which encapsulate RNA molecules and protect them from degradation.
• Glycerides, especially monoacylglycerols, can form self-assembling structures that can be used for RNA delivery.

Although glycerides have been explored for RNA delivery, it is worth noting that their use in this regard is still an area of ongoing research and development. The specific selection of glycerides and their formulation in lipid delivery systems should be carefully evaluated to ensure adequate RNA protection, efficient cellular uptake, and minimal cytotoxicity.

Reference

1. Domínguez, Rubén; et al. Chapter 1 - Introduction and Classification of Lipids. Food Lipids. 2022, 1-16.

Our products and services are for research use only and cannot be used for any clinical purposes.

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