Vaccine Lab / Alfa Chemistry
Guanidine Hydrochloride
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Guanidine Hydrochloride

Guanidine hydrochloride is a strong protein denaturant that functions as a chaotropic agent. As a typical chemical denaturant, guanidine hydrochloride has two amino groups on the molecular structure, which can form new hydrogen bonds with the hydroxyl, carboxyl and amino groups of collagen molecules, thus replacing the intermolecular and intramolecular partial hydrogen bonds of the original collagen molecules. These changes result in the conformation or aggregation of the protein [1]. At high concentrations of guanidine hydrochloride, proteins lose their ordered structure and they tend to curl randomly, i.e. without any residual structure. However, at concentrations in the millimolar range in vivo, guanidine hydrochloride has been shown to cure prion-positive yeast cells. As a unique organic compound, guanidine hydrochloride currently plays an important role in the application of biomedicine and other fields.

Structural formula of guanidine hydrochloride.Figure 1. Structural formula of guanidine hydrochloride.

Product Details

Product NameGuanidine hydrochloride
CAS Number50-01-1
SynonymsGuanidine HCl, Guanidinium chloride, Guanidine hydrochloride, Guanidine chloride, etc.
Molecular FormulaCH5N3.ClH
Molecular Weight95.53 g/mol
AppearanceWhite to almost white powder to crystal
Melting Point180-185 °C (lit.)
Density1.3 g/cm3 (lit.)
Heavy Metals (as Pb)≤0.001%
Loss on Drying≤0.5 %
Insoluble Matter≤0.15 %
Storage ConditionStorage at room temperature
NoteThis product is for research use only.

Product Applications

  • This product can be used for denaturation and renaturation of proteins.
  • This product can be used for the purification of RNA by dissociating the RNA into its nucleic acid and protein forms.
  • This product can be used as an intermediate for drugs and is an important raw material for the production of sulfadiazine, sulfamethazine, and folic acid.

Since the SARS-CoV-2 pandemic, research into the detection and treatment of Coronavirus has never stopped. Alfa Chemistry is committed to providing customers with the guanidine hydrochloride used in the nucleic acid detection process to meet their various needs. If the product you are looking for is not in our catalog, please contact us. We will be happy to provide you with customized synthesis services.


  1. He, H. X.; et al. Solubility measurement, molecular simulation and thermodynamic analysis of guanidine hydrochloride in eleven neat solvents. Journal of Molecular Liquids. 2021, 339: 116468.

Our products and services are for research use only and cannot be used for any clinical purposes.

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