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CONTACT USGuanidine hydrochloride is a strong protein denaturant that functions as a chaotropic agent. As a typical chemical denaturant, guanidine hydrochloride has two amino groups on the molecular structure, which can form new hydrogen bonds with the hydroxyl, carboxyl and amino groups of collagen molecules, thus replacing the intermolecular and intramolecular partial hydrogen bonds of the original collagen molecules. These changes result in the conformation or aggregation of the protein [1]. At high concentrations of guanidine hydrochloride, proteins lose their ordered structure and they tend to curl randomly, i.e. without any residual structure. However, at concentrations in the millimolar range in vivo, guanidine hydrochloride has been shown to cure prion-positive yeast cells. As a unique organic compound, guanidine hydrochloride currently plays an important role in the application of biomedicine and other fields.
Figure 1. Structural formula of guanidine hydrochloride.
| Product Name | Guanidine hydrochloride |
| CAS Number | 50-01-1 |
| Synonyms | Guanidine HCl, Guanidinium chloride, Guanidine hydrochloride, Guanidine chloride, etc. |
| Molecular Formula | CH5N3.ClH |
| Molecular Weight | 95.53 g/mol |
| Appearance | White to almost white powder to crystal |
| Melting Point | 180-185 °C (lit.) |
| Density | 1.3 g/cm3 (lit.) |
| Purity | ≥99.5% |
| Heavy Metals (as Pb) | ≤0.001% |
| Loss on Drying | ≤0.5 % |
| Insoluble Matter | ≤0.15 % |
| Storage Condition | Storage at room temperature |
| Note | This product is for research use only. |
Since the SARS-CoV-2 pandemic, research into the detection and treatment of Coronavirus has never stopped. Alfa Chemistry is committed to providing customers with the guanidine hydrochloride used in the nucleic acid detection process to meet their various needs. If the product you are looking for is not in our catalog, please contact us. We will be happy to provide you with customized synthesis services.
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