Selection of Vaccine Adjuvants

Adjuvants have been shown to be a key component of subunit vaccines and certain inactivated vaccines. Vaccine adjuvants can not only change the type of immune response, the type and subclass of immunoglobulin, but also change the state of immune response, reduce the immune tolerance of the body, and make the body produce immune response rapidly. The earliest vaccine adjuvant appeared in the 19th century. It is a natural component of rabies vaccines, known as single-stranded ribonucleic acid. Subsequently, some scientists found that agar, metal salts, lecithin and saponins added to vaccines can also non-specifically enhance the immunogenicity of antigens. Until now, aluminum salts, Freund's adjuvant and lipopolysaccharide have been successively shown to have adjuvant activity. Adjuvant molecules must be appropriately formulated for both maximum effect and stability. Alfa Chemistry offers vaccine adjuvant selection services to ensure that adjuvants will be safe, stable prior to administration, readily biodegradable and eliminated, able to promote antigen-specific immune responses, cost effective to produce, and easy to use.

Potential benefits of vaccine adjuvants

Investigators may seek to include specific adjuvants in vaccine candidates to enhance the potency of weak antigens, to induce appropriate immune responses not sufficiently induced in the absence of adjuvant or both. It can be said that adjuvants help the vaccine work better. The benefits of adding appropriate adjuvants to the vaccine are as follows.

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Since their discovery in the beginning of the 20th century, vaccine adjuvants have been used to improve immune responses that ultimately lead to protection against disease. The choice of the vaccine adjuvant is of utmost importance as it can stimulate strong humoral and cell mediated immunity indispensable for protection against some pathogens. Alfa Chemistry offers adjuvant selection services based on several parameters, including the physical and chemical natures of the vaccine antigen (soluble, particulate, charge etc.), the type of immune response desired, the age of the target population, the route of vaccine administration, and the stability of the vaccine. The desired qualities of each particular vaccine may necessitate adjuvants with specific properties. Our adjuvant selection service is dedicated to providing the most suitable adjuvants for different vaccine studies.

Why choose us

By utilizing our experienced experts to work with your team, Alfa Chemistry helps you select the most appropriate vaccine adjuvants for your research. This will save you cost and time. If you have any questions related to vaccine adjuvants, please feel free to contact us. Alfa Chemistry is always your project partner.

Our products and services are for research use only and cannot be used for any clinical purposes.

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Selection of Vaccine Adjuvants

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