Vaccine Lab / Alfa Chemistry
SARS-CoV-2 Spike Neutralizing Antibody
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SARS-CoV-2 Spike Neutralizing Antibody

Note: This product is for research use only.

Product Details

IsotypeHuman IgG1, kappa
ConjugateThis product is un-conjugated.
ApplicationsELISA, Neutralization
Recommended dilution: ELISA, 0.05-1 µg/mL
SpecificityThis product can recognize the Spike protein RBD domain of the SARS virus and block the binding of ACE-2 receptor.
ImmunogenRecombinant SARS-CoV-2 Spike RBD Protein
PurificationProtein A, Affinity Chromatography
Buffer0.2 μm filtered solution in PBS

Shipping & Storage Information

ShippingThis product is shipped in dry ice unless customers require otherwise.
StorageThis product can be stored at 2-8 °C for one year.
This product can be stored at −20 to −80 °C for three years.
Please avoid freeze-thaw cycles.

Target Background Information

The spike (S) protein of coronavirus is the main target for the development of vaccines and a potential strategy to counteract viral entry into human cells. The S protein forms a trimer at the protrusion of the virus and consists of two functional subunits: S1 and S2 [1]. The S protein mediates viral entry into host cells by first binding to a host receptor through the receptor-binding domain (RBD) in the S1 subunit and then fusing the viral and host membranes through the S2 subunit [2]. Neutralizing antibodies mainly target the S protein in the coronavirus, especially the S1 subunit and the RBD contained in the S1 subunit, preventing the virus from entering the host cell and causing infection.

Neutralizing antibodies bind to spike proteins and prevent the virus from binding and entering the human cell.Figure 1. Neutralizing antibodies bind to spike proteins and prevent the virus from binding and entering the human cell.

Since the SARS-CoV-2 pandemic, research into the detection and treatment of Coronavirus has never stopped. Alfa Chemistry is committed to providing customers with a series of antibodies for diagnostics to meet the various needs of customers. If the product you are looking for is not in our catalog, please contact us. We will be happy to provide you with customized synthesis services.


  1. Peter, E. K.; et al. The inhibitory effect of a coronavirus spike protein fragment with ACE2. Biophysical Journal. 2021, 120(6): 1001-1010.
  2. Tai, W.; et al. Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine. Cellular & molecular immunology. 2020, 17(6): 613-620.

Our products and services are for research use only and cannot be used for any clinical purposes.

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