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| Isotype | Human IgG1, kappa |
| Conjugate | This product is un-conjugated. |
| Applications | ELISA, Neutralization Recommended dilution: ELISA, 0.05-1 µg/mL |
| Specificity | This product can recognize the Spike protein RBD domain of the SARS virus and block the binding of ACE-2 receptor. |
| Immunogen | Recombinant SARS-CoV-2 Spike RBD Protein |
| Concentration | 1mg/mL |
| Purification | Protein A, Affinity Chromatography |
| Buffer | 0.2 μm filtered solution in PBS |
| Shipping | This product is shipped in dry ice unless customers require otherwise. |
| Storage | This product can be stored at 2-8 °C for one year. This product can be stored at −20 to −80 °C for three years. Please avoid freeze-thaw cycles. |
The spike (S) protein of coronavirus is the main target for the development of vaccines and a potential strategy to counteract viral entry into human cells. The S protein forms a trimer at the protrusion of the virus and consists of two functional subunits: S1 and S2 [1]. The S protein mediates viral entry into host cells by first binding to a host receptor through the receptor-binding domain (RBD) in the S1 subunit and then fusing the viral and host membranes through the S2 subunit [2]. Neutralizing antibodies mainly target the S protein in the coronavirus, especially the S1 subunit and the RBD contained in the S1 subunit, preventing the virus from entering the host cell and causing infection.
Figure 1. Neutralizing antibodies bind to spike proteins and prevent the virus from binding and entering the human cell.
Since the SARS-CoV-2 pandemic, research into the detection and treatment of Coronavirus has never stopped. Alfa Chemistry is committed to providing customers with a series of antibodies for diagnostics to meet the various needs of customers. If the product you are looking for is not in our catalog, please contact us. We will be happy to provide you with customized synthesis services.
Our products and services are for research use only and cannot be used for any clinical purposes.
Alfa Chemistry is a global leader in the vaccine industry. We have the ability to help our customers meet the challenges of various vaccine development processes. Alfa Chemistry believes that partnerships will change the way the world innovates, bringing new technologies.
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