Product Name: Dengue Virus Serotype 1 Virus-Like Particles (Gen.2)
Catalog Number: ACVL-VLP003
Category: Virus-Like Particles (VLPs)
Host System: HEK293 Stable Cell Line (Mammalian)
Components: Envelope (E), pre-Membrane (prM), Membrane (M)
Product Overview
Dengue Virus Serotype 1 VLP (Gen.2) represents an advanced recombinant antigen system developed to address reproducibility and scalability challenges in flavivirus research. Built on a stably transfected HEK293 cell line, this platform enables continuous and controlled production of virus-like particles with reduced batch variability.
The resulting particles maintain key structural characteristics of DENV-1 surface proteins while offering a more consistent manufacturing profile, making them suitable for studies requiring standardized materials across multiple experimental cycles.
Product Advantages
Integration of expression constructs into the host genome ensures long-term, uniform protein production.
- Enhanced Batch Consistency
Minimized variation between production lots supports reproducible experimental outcomes.
- Scalable Manufacturing Capability
Adaptable to larger culture volumes, facilitating preclinical and process development workflows.
Maintains conformational integrity of viral proteins while improving production robustness.
Technical Specifications
| Item | Specification |
| Product Name | Dengue Virus Serotype 1 Virus-Like Particles (Gen.2) |
| Catalog Number | ACVL-VLP003 |
| Expression System | HEK293 stable mammalian cell line |
| Components | Envelope (E), pre-Membrane (prM), and Membrane (M) |
| Sequence Reference | NCBI Accession ACA48859.1 |
| Formulation | Provided in optimized buffer for maximum stability |
Applications
- Preclinical Vaccine Development: Supports evaluation of vaccine candidates requiring consistent antigen input.
- Assay Standardization: Provides a reliable antigen source for assay validation and cross-study comparison.
- Neutralizing Antibody Analysis: Suitable for quantitative and comparative antibody studies.
- Process Development: Applicable in upstream/downstream optimization and analytical method development.
Product Positioning
This second-generation VLP is optimized for scale-up research, assay standardization, and translational studies, where reproducibility and supply stability are critical.
In addition to DENV-1 VLP (Gen.2), Alfa Chemistry also offers virus-like particles representing Dengue Virus Serotypes 2, 3, and 4, supporting multivalent vaccine research and comparative flavivirus studies.
Our products and services are for research use only and cannot be used for any clinical purposes.
