Chikungunya Virus-Like Particles

Product Name: Chikungunya Virus-Like Particles
Catalog Number: ACVL-VLP001
Category: Virus-Like Particles (VLPs)
Host System: HEK293 (Mammalian)
Components: Recombinant E1, E2, and Capsid Proteins
Purity: >90% (by SDS-PAGE and HPLC)

Product Overview

Alfa Chemistry offers high-quality Chikungunya Virus-Like Particles (VLPs) designed to support vaccine research, immunological studies, and diagnostic development. Produced through transient expression in human HEK293 cells, these VLPs consist of the viral structural proteins E1, E2, and capsid (C).

Unlike conventional recombinant proteins, these structural components self-assemble into multi-protein nanoparticles that closely mimic the architecture of native Chikungunya virus (CHIKV) particles. Because the particles lack viral genomic RNA and non-structural proteins, they are completely non-infectious while maintaining authentic antigen presentation.

With native-like folding and mammalian glycosylation patterns, these VLPs preserve key conformational epitopes found on the viral envelope. This makes them highly suitable for applications requiring biologically relevant viral antigens, including vaccine development, antibody discovery, and serological assay development.

Key Technical Features

• Authentic Post-Translational Modifications: Production in HEK293 mammalian cells ensures native-like glycosylation and protein folding, which are critical for maintaining conformational neutralizing epitopes.
• Structural Integrity: Advanced purification using density-gradient ultracentrifugation and chromatographic methods yields VLPs with morphology similar to native virions, typically measuring approximately 50–70 nm in diameter.
• High Purity: Optimized purification processes produce VLP preparations with >90% purity, minimizing background interference in sensitive research applications.
• Optimized Antigenicity: The preserved envelope structure allows strong recognition by virus-specific antibodies, making these VLPs suitable for high-specificity diagnostic assay development.

Background & Therapeutic Significance

Chikungunya virus (CHIKV) is an arthropod-borne virus belonging to the Alphavirus genus within the Togaviridae family. Transmitted primarily by Aedes mosquitoes, CHIKV infection causes Chikungunya fever, a disease characterized by high fever, rash, and severe joint pain that may persist for months. Due to the overlapping symptoms between Chikungunya, Dengue, and Zika infections, accurate diagnostic tools are essential for effective clinical management and epidemiological monitoring.

Virus-like particle technology has emerged as a promising strategy in modern vaccine research. By presenting viral antigens in a highly ordered and repetitive configuration, VLPs can efficiently stimulate immune responses while maintaining an excellent safety profile due to the absence of viral genetic material.

Applications

• Vaccine Development: Serve as a primary immunogen or scaffold in preclinical vaccine trials and efficacy studies.
• Diagnostic Assays: Act as a high-fidelity coating antigen for ELISA, lateral flow, and other serological platforms to distinguish CHIKV from other arboviruses.
• Antibody Screening: Useful in the discovery and characterization of therapeutic monoclonal antibodies.
• Structural Biology: Ideal for high-resolution imaging and studies on viral entry mechanisms.

Technical Specifications

Why Choose Alfa Chemistry?

At Alfa Chemistry, we combine deep expertise in virology with state-of-the-art bioprocessing. Our Chikungunya Virus VLPs are rigorously tested for consistency, ensuring that your research transitions seamlessly from the laboratory to clinical development. We provide scalable solutions and comprehensive technical support to meet the rigorous demands of the global life sciences community.

Our products and services are for research use only and cannot be used for any clinical purposes.

Online Inquiry

Chikungunya Virus-Like Particles

Send A Message