Description |
N,N-ditetradecylamine-N-succinyl[methyl(polysarcosine)35] Polypeptoid-lipid conjugates based on the amino acid sarcosine (pSar) have become a promising alternative to PEGylated lipids. When formulating LNPs, pSar lipids of varying polymeric chain lengths have been used to tune physical properties such as particle size, morphology, and internal structure. Not only are they used to alter the physical characteristics of LNPs, but pSar LNPs have also proven to be an excellent mRNA transfection agent. Comparing pSar lipid to PEGylated lipid LNP formulations showed a more robust mRNA transfection potency while also improving the safety profile. |