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CONTACT USVaccines are formulated using various components, including antigens, adjuvants, and stabilizers, to ensure their effectiveness and safety. One of the most commonly used stabilizers in vaccines is sucrose, a naturally occurring disaccharide. Sucrose plays a vital role in vaccine formulation, helping to maintain stability and enhance the shelf-life of vaccines.
Lyophilization, commonly known as freeze-drying, is a process used to increase the shelf-life of vaccines. It involves removing water from the formulation, thus preventing degradation and microbial growth. Sucrose plays a critical role in this process, acting as a cryoprotectant. During freeze-drying, the addition of sucrose creates a glassy matrix that surrounds the antigens, stabilizing their structure and allowing them to maintain their immunogenicity even after reconstitution.
The specific formulas of vaccines may vary from different manufacturers and countries. The following table lists some common U.S. vaccines containing sucrose ingredients for reference only.
| Vaccine | Contains |
| COVID-19 Vaccine (COMIRNATY) | messenger ribonucleic acid (mRNA), tromethamine, tromethamine hydrochloride, sucrose. |
| Adenovirus | monosodium glutamate, sucrose, D-mannose, D-fructose, dextrose, human serum albumin, potassium phosphate, plasdone C… |
| Cholera (Vaxchora) | ascorbic acid, hydrolyzed casein, sodium chloride, sucrose, dried lactose, sodium bicarbonate, sodium carbonate. |
| DTaP-IPV/Hib (Pentacel) | aluminum phosphate, polysorbate 80, sucrose, formaldehyde, glutaraldehyde, bovine serum albumin… |
| Hib (ActHIB) | sodium chloride, formaldehyde, sucrose. |
| Influenza (Afluria) | sodium chloride, monobasic sodium phosphate, ovalbumin, sucrose, neomycin sulfate, polymyxin B... |
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It is always recommended to check the vaccine package insert on the FDA's official website.
Vaccines Licensed for Use in the United States
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