CAS 1984-06-1 Sodium Octanoate - Vaccine Lab / Alfa Chemistry

The Protective Role of Sodium Octanoate in Traumatic Cardiac Arrest

Sodium octanoate alleviates cardiac and cerebral injury after traumatic cardiac arrest in a porcine model Lin Y, et al. The American Journal of Emergency Medicine, 2024, 78, 48-56.

The study indicates that early administration of sodium octanoate can significantly alleviate cardiac and cerebral injuries following traumatic cardiac arrest (TCA) by inhibiting apoptosis and ferroptosis. These findings suggest that sodium octanoate could offer a novel therapeutic approach for improving outcomes in TCA patients by protecting against post-resuscitation damage.
Methods: The study utilized 22 male domestic pigs, divided into three groups: Sham (n = 7), TCA (n = 7), and sodium octanoate (SO) (n = 8). TCA was induced by hemorrhage via the right femoral artery. The Sham group underwent endotracheal intubation and catheterization without blood loss or resuscitation. Five minutes post-resuscitation, the SO group received a continuous infusion of sodium octanoate, while the TCA group received saline. Biomarkers for cardiac and cerebral injury were monitored at baseline and various time points, and samples of heart and brain tissues were analyzed for apoptosis, iron deposition, oxidative stress, and ferroptosis-related protein expression (ACSL4 and GPX4).
Results: Sodium octanoate infusion significantly improved mean arterial pressure, cardiac output, and ejection fraction post-TCA. The SO group exhibited lower levels of serum biomarkers indicative of cardiac and cerebral injury compared to the TCA group. Furthermore, sodium octanoate reduced apoptosis rates in cardiomyocytes and cerebral cortex cells and decreased iron deposition and oxidative stress. It also downregulated ferroptosis by modulating ACSL4 and GPX4 protein levels.

Catalog Number	ACM1984061-2
CAS	1984-06-1
Structure
Synonyms	Octanoic acid-2,4,6,8-13C4 sodium salt
IUPAC Name	sodium;octanoate
Molecular Weight	166.19
Molecular Formula	C8H15NaO2
Canonical SMILES	CCCCCCCC(=O)[O-].[Na+]
InChI	InChI=1S/C8H16O2.Na/c1-2-3-4-5-6-7-8(9)10;/h2-7H2,1H3,(H,9,10);/q;+1/p-1
InChI Key	BYKRNSHANADUFY-UHFFFAOYSA-M
Melting Point	245 °C (dec.)
Purity	≥99%
Solubility	Soluble in water
Appearance	Powder
Complexity	94.1
Covalently-Bonded Unit Count	2
Defined Atom Stereocenter Count	0
EC Number	217-850-5
Exact Mass	166.09697400
Heavy Atom Count	11
Hydrogen Bond Acceptor Count	2
Hydrogen Bond Donor Count	0
Isomeric SMILES	CCCCCCCC(=O)[O-].[Na+]
Monoisotopic Mass	166.09697400
pH	8.0-10.5 (100g/L in H₂O, 20°C)
Physical State	Solid
Rotatable Bond Count	6
Storage Conditions	Room temperature
Topological Polar Surface Area	40.1 Å²