CAS 145224-92-6 Sodium deoxycholate monohydrate

Sodium Deoxycholate Monohydrate for Modification of Zeinolysin Nanoparticles

Paclitaxel-loaded sodium deoxycholate-stabilized zein nanoparticles: characterization and in vitro cytotoxicity Gagliardi A, et al. Heliyon, 2019, 5(9), e02422.

Sodium deoxycholate monohydrate (SD) can be used to modify zeinolysin nanoparticles to stabilize the colloidal structure. The zeinolysin nanoparticles loaded with paclitaxel (PTX) were prepared as follows:
First, 10 mg of zeinolysin was dissolved in 3 ml of an ethanol/water solution (2:1 v/v) at room temperature. This solution was then added to 5 ml of an aqueous phase consisting of MilliQ water containing 1.25% w/v SD. The mixture was homogenized for 1 minute at 24,000 rpm, followed by mechanical stirring for 12 hours at 600 rpm on a magnetic stirrer to facilitate the evaporation of the organic solvent. Zeaxanthin nanoparticles containing PTX were obtained by adding varying amounts of PTX to the organic phase.

Catalog Number	ACM145224926-1
CAS	145224-92-6
Structure
Synonyms	Desoxycholic acid sodium salt; 3α,12α-Dihydroxy-5β-cholanic acid sodium salt; 7-Deoxycholic acid sodium salt
IUPAC Name	sodium;(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
Molecular Weight	432.57
Molecular Formula	C24H41NaO5
Canonical SMILES	CC(CCC(=O)[O-])C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C.O.[Na+]
InChI	InChI=1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1
InChI Key	FHHPUSMSKHSNKW-SMOYURAASA-M
Melting Point	>300 °C
Purity	≥98%
Solubility	Soluble in water
Appearance	White powder
Complexity	612
Covalently-Bonded Unit Count	3
Defined Atom Stereocenter Count	10
EC Number	206-132-7
Exact Mass	414.27460400
Heavy Atom Count	29
Hydrogen Bond Acceptor Count	4
Hydrogen Bond Donor Count	2
Isomeric SMILES	C[C@H](CCC(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C.[Na+]
Monoisotopic Mass	414.27460400
pH	7.5-9.5 (0.1M in H₂O, 25 °C)
Physical State	Solid
Rotatable Bond Count	4
Shipping	Ambient temperature
Storage Conditions	Ambient temperature
Topological Polar Surface Area	80.6 Å²