Vaccine Lab / Alfa Chemistry
Sodium chenodeoxycholate

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Sodium chenodeoxycholate

Catalog Number ACM2646380-3
CAS 2646-38-0
Structure
Synonyms Chenodesoxycholic acid; 5β-Cholanic acid-3α,7α-diol
IUPAC Name sodium;(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
Molecular Weight 414.55
Molecular Formula C24H39NaO4
Canonical SMILES CC(CCC(=O)[O-])C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C.[Na+]
InChI InChI=1S/C24H40O4.Na/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26;/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-;/m1./s1
InChI Key WDFRNBJHDMUMBL-OICFXQLMSA-M
Melting Point 298 °C (dec.)
Purity 97%
Complexity 612
Covalently-Bonded Unit Count 2
Defined Atom Stereocenter Count 10
EC Number 627-685-4
Exact Mass 414.27460400
Heavy Atom Count 29
Hydrogen Bond Acceptor Count 4
Hydrogen Bond Donor Count 2
Isomeric SMILES C[C@H](CCC(=O)[O-])[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C.[Na+]
MDL Number MFCD00065452
Monoisotopic Mass 414.27460400
Rotatable Bond Count 4
Topological Polar Surface Area 80.6 Ų
Knowledge & Learning Case Study Q&A

Sodium Chenodeoxycholate for Biosurfactant-Assisted Mechanical Amorphous Dispersion Extraction

Simultaneous capture of hydrophilic and hydrophobic compounds from complex plants by biosurfactant-assisted mechanical amorphous dispersion extraction Zhu S-C, et al. Journal of Chromatography A, 2022, 1678, 463356.

Sodium chenodeoxycholate (Na-CDC), a bile salt-derived biosurfactant, has gained significant attention in recent years for its potential in enhancing extraction methods in phytochemical analysis. Its amphiphilic structure allows it to effectively interact with both hydrophilic and hydrophobic compounds, making it a versatile agent in the extraction of diverse bioactive constituents from complex matrices.
A recent study demonstrated the successful application of Na-CDC in a biosurfactant-assisted mechanical amorphous dispersion extraction (BA-MADE) method for Salvia miltiorrhiza samples. Under the optimized conditions, 407.02 mg of Na-CDC, a grinding time of 4.87 minutes, an extraction time of 4.92 minutes, and a solid-to-liquid ratio of 0.5:10 g/mL were found to yield superior extraction results. The method showed high precision and accuracy, with limits of detection ranging from 5.46 to 130 ng/mL and recoveries of the real sample ranging from 85% to 113%. In comparison with conventional extraction methods, such as heating reflux extraction, ultrasonic extraction, and microwave-assisted micellar extraction, the BA-MADE method demonstrated significant advantages in terms of efficiency and simultaneous extraction of hydrophilic and hydrophobic compounds.

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