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CONTACT US| Catalog Number | ACM9005087-2 |
| CAS | 9005-08-7 |
| Description | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. |
| Synonyms | Octadecanoic acid glycerol ester |
| Molecular Weight | 332.52 |
| Molecular Formula | C19H40O4 |
| Canonical SMILES | OCCO.CCCCCCCCCCCCCCCCC(O)=O |
| Melting Point | 35-37 °C |
| Purity | 99% |
| Application | Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. |
| MDL Number | MFCD00084419 |
| Physical State | Solid |
| PubChem ID | 24858431 |
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Zhang H, et al. Materials Research Bulletin, 2008, 43(11), 2979-2985.
Poly(ethylene glycol) distearate (PEGDS) can serve as a template for synthesizing highly ordered layered mesostructured silica in an ethanol solution. The resulting materials exhibit large layer spacing, excellent thermal and mechanical stability, and are well-suited for polymer intercalation in layered mesostructured silica, facilitating the preparation of in situ polymerized nanocomposites.
A typical synthesis procedure for layered mesostructured silica is as follows: PEGDS (1.50 g) is dissolved in ethanol (30.0 g) and stirred at 35 °C for 3 hours to form a template solution containing surfactant micelles. In a separate beaker, Tetraethoxysilane (TEOS) (5.0 g) is mixed with an appropriate amount of HCl solution (3.0 g) and stirred at 35 °C until a homogeneous solution is obtained, indicating the completion of TEOS hydrolysis. The two solutions are then combined and stirred for 24 hours, resulting in a final pH of approximately 6.95. The precipitated product is washed with deionized water, air-dried at room temperature for one week, and then calcined at 550 °C for 6 hours to remove the template.
What is the molecular weight of Poly(ethylene glycol) distearate?
The molecular weight of Poly(ethylene glycol) distearate is 332.52.
What is the molecular formula of Poly(ethylene glycol) distearate?
The molecular formula of Poly(ethylene glycol) distearate is C19H40O4.
What is the melting point of Poly(ethylene glycol) distearate?
The melting point of Poly(ethylene glycol) distearate is 35-37 °C.
What are some synonyms for Poly(ethylene glycol) distearate?
One synonym for Poly(ethylene glycol) distearate is Octadecanoic acid glycerol ester.
How can Poly(ethylene glycol) distearate be used in bioconjugation applications?
Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications.
What are some applications of PEGylated materials?
PEGylated materials have found broad use in drug delivery systems, virology, and immunology.
What are some features and benefits of Poly(ethylene glycol) distearate?
Some features and benefits include high quality products, fast delivery, and the option to order additional products.
What is the Quality Level of Poly(ethylene glycol) distearate?
The Quality Level of Poly(ethylene glycol) distearate is 200.
How can activated PEG derivatives be used in tissue engineering applications?
Activated PEG derivatives can be used to form networks for tissue engineering applications.
How does PEGylation improve the pharmacological properties of compounds?
Incorporating PEG improves properties such as increased water solubility, enhanced resistance to degradation, increased circulation half-life, and reduced antigenicity.
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