Description |
N,N-ditetradecyl-polysarcosine-25 Polysarcosine (pSar, a polypeptoid based on the amino acid sarcosine) lipids have become a promising alternative to PEGylated lipids. When formulating LNPs, pSar lipids of varying polymeric chain lengths have been used to tune physiochemical properties such as particle size, morphology, and internal structure. Aside from being able to change the physical nature of the LNP, pSar LNPs have also proven to be an excellent mRNA transfection agent. When compared to similar LNPs formulated with PEGylated lipids, LNPs formulated with pSar lipids exhibited a more robust mRNA transfection potency while also showing an improved safety profile. |