L-α-phosphatidylcholine (soy)

Catalog Number	ACM97281475-1
CAS	97281-47-5
Structure
Description	Phosphatidylcholines,soya is a phosphatidylcholine extracted from soybeans and can be used in the preparation of liposomes.
Synonyms	Phosphatidylcholines, soya
Molecular Weight	758.06
Molecular Formula	C42H80NO8P
InChI	1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
InChI Key	JLPULHDHAOZNQI-ZTIMHPMXSA-N
Flash Point	>93 °C
Purity	98%+
Application	Phosphatidylcholines,soya can be used as carriers for animal administration.
API Family	phosphatidylcholine
EC Number	306-547-4
Exact Mass	757.562134
Grade	pharmaceutical primary standard
In Vitro Studies	Fibroblasts are sensitive to soy phosphatidylcholine liposomes with an IC50 of 150 μM.
LogP	10.9
NACRES	NA.24
Physical State	Yellow to brown viscous liquid or paste, powder or granules
Storage Conditions	Stored at -20 °C
WGK Germany	1

Knowledge & Learning Case Study Q&A

Construction and Application of L-α-Phosphatidylcholine Based Liposomes

Among the diverse lipid constituents of liposomes, L-α-phosphatidylcholine (L-α-PC) stands out as a highly advantageous and widely used amphiphilic phospholipid. Here you can discover the research and application of L-α-phosphatidylcholine in liposome construction, vaccine development and drug delivery. Get more information on:

• What Is L-α-Phosphatidylcholine?
• L-α-PC for Liposome Construction
• L-α-PC Based Liposome for Vaccine Development
• L-α-PC Based Liposome for Drug Delivery

Phosphatidylcholine-Based Delivery Systems for Vaccine Development

Phosphatidylcholine (PC), being a key constituent of liposomes, has been extensively studied for encapsulating and delivering various vaccines. Liposomes composed of phosphatidylcholine offer a biocompatible and biodegradable platform for antigen delivery. Research by Gregoriadis and Allison demonstrated that liposomes containing phosphatidylcholine enhanced the immunogenicity of encapsulated antigens, thereby promoting effective vaccine delivery. Get more information on:

• Phosphatidylcholine-Based Delivery System
• Advantages of Phosphatidylcholine-Based Delivery Systems
• Common Phosphatidylcholine from Alfa Chemistry
• Application Forms of Phosphatidylcholine in Vaccines
• Applications in Vaccine Development

Modification of L-α-Phosphatidylcholine for Polymer-based Stationary Phases

Dana Moravcová D, et al. Journal of Chromatography A, 2015, 1402, 27-35.

In this case study, L-α-Phosphatidylcholine extracted from soybeans (soyPC) was used to modify a methacrylate-based monolithic column in a capillary format via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide coupling, creating a stationary phase suitable for simulating cell surface membranes. The method for functionalizing the poly(GMA-co-EDMA) monolith with SoyPC is as follows:
The capillaries containing the monolithic substrate were initially flushed with water, followed by 2 M aqueous HMD solution at 60℃ for 2 hours at a flow rate of 60 μL/h. Next, the column was filled with 1 M aqueous GA solution, sealed with septum caps, and left at room temperature for 12 hours. Afterward, the column was flushed with water and methanol (MeOH). The modification step with 2 M HMD solution was repeated, and subsequently, the column was filled with a mixture containing 100 mM EDC and 150 mM soyPC dissolved in 0.1 M imidazole in MeOH. The column was sealed with septum caps and allowed to react for 30 minutes at room temperature. Following this, the column was filled with an aqueous solution of 0.2 M SCBH and left to react for 2 hours at 4℃. Finally, the column was washed with MeOH and isopropanol (IPA) to eliminate any soyPC adsorbed to the monolith through Van der Waals interactions.

L-α-phosphatidylcholine for the Synthesis of L-α-glycerylphosphorylcholine

Song Y, et al. J. Agric. Food Chem, 2020, 68(44), 12375-12383.

In this case, L-α-glycerylphosphorylcholine (L-α-GPC) was prepared by catalytic hydrolysis of soybean PC (L-α-phosphatidylcholine) using immobilized Lecitase Ultra (LU). The preparation method is as follows:
The reaction is conducted in a flat-bottom glass container equipped with a water jacket to control the temperature. The container is preheated to the desired temperature using a water circulator. Then, 4 g of soybean PC is mixed with 16 mL of n-hexane, the required volume of water, and an immobilized enzyme. During the reaction, the mixture is stirred with a magnetic stirrer at a frequency of 10 Hz.
L-α-GPC is purified through phase separation in a biphasic medium of n-hexane and water. The reaction product is filtered under vacuum through Whatman No. 41 filter paper to remove the immobilized enzyme. The reaction vessel is washed with water and filtered as described above. The combined filtrate and washings are mixed with water and n-hexane in a separatory funnel to dissolve L-α-GPC and free fatty acids, respectively. After phase separation, the bottom aqueous layer is collected, dried in a rotary vacuum evaporator at 60°C, and further dried under nitrogen purging to obtain L-α-GPC.

What is the chemical name for L-α-phosphatidylcholine (soy)?

The chemical name for L-α-phosphatidylcholine (soy) is 1,2-Distearoyl-sn-glycero-3-phosphocholine or DSPC.

What is the CAS number for L-α-phosphatidylcholine (soy)?

The CAS number for L-α-phosphatidylcholine (soy) is [816-94-4].

What is the molecular formula of L-α-phosphatidylcholine (soy)?

The molecular formula of L-α-phosphatidylcholine (soy) is C44H88NO8P.

What is the molecular weight of L-α-phosphatidylcholine (soy)?

The molecular weight of L-α-phosphatidylcholine (soy) is 790.15 g/mol.

What is the storage recommendation for L-α-phosphatidylcholine (soy)?

It is recommended to store L-α-phosphatidylcholine (soy) at temperatures below -15°C and to close the container well.

What is the role of L-α-phosphatidylcholine (soy) in liposomal delivery systems?

L-α-phosphatidylcholine (soy) is a formulation component for drugs in liposomal delivery systems.

What is another name for L-α-phosphatidylcholine (soy)?

Another name for L-α-phosphatidylcholine (soy) is Distearoyl-L-α-lecithin.

Is L-α-phosphatidylcholine (soy) a charged or uncharged cell membrane phospholipid?

L-α-phosphatidylcholine (soy) is an uncharged cell membrane phospholipid.

What are the precautionary statement codes associated with L-α-phosphatidylcholine (soy)?

The precautionary statement codes associated with L-α-phosphatidylcholine (soy) are P261 and P262.

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