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CONTACT US| Catalog Number | ACM110270-2 |
| CAS | 110-27-0 |
| Structure |  |
| Description | Ester of isopropyl alcohol and myristic acid (vegetable-derived). Low viscosity fluid non-greasy emollient, tolerates wide pH range, compatible with most surfactants. Thanks to its low viscosity and density, it has a high spreadability. Specific gravity 0.85 (at 20°C). |
| Synonyms | 1-Methylethyl tetradecanoate |
| IUPAC Name | Propan-2-yl tetradecanoate |
| Molecular Weight | 270.5 |
| Molecular Formula | C17H34O2 |
| Canonical SMILES | CCCCCCCCCCCCCC(=O)OC(C)C |
| InChI | InChI=1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3 |
| InChI Key | AXISYYRBXTVTFY-UHFFFAOYSA-N |
| Boiling Point | 193 °C |
| Melting Point | 3 °C |
| Flash Point | >230 °F |
| Purity | 95%+ |
| Density | 0.85 g/mL at 25 °C(lit.) |
| Solubility | Water-insoluble, but soluble with silicones, and hydrocarbons |
| Appearance | Colorless oil-like liquid, odorless |
| Application | Creams, lotions, hand creams, shampoo, shower gels, makeup removers, powders and foundations. |
| Storage | Store in a closed container at a dry place at room temperature |
| Complexity | 199 |
| Composition | Isopropyl myristate |
| Covalently-Bonded Unit Count | 1 |
| Defined Atom Stereocenter Count | 0 |
| EC Number | 203-751-4 |
| Exact Mass | 270.255880323 |
| Heavy Atom Count | 19 |
| Hydrogen Bond Acceptor Count | 2 |
| Hydrogen Bond Donor Count | 0 |
| LogP | 5.63910 |
| MDL Number | MFCD00008982 |
| Monoisotopic Mass | 270.255880323 |
| Physical State | Liquid |
| Rotatable Bond Count | 14 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Storage Conditions | 2-8 °C |
| Topological Polar Surface Area | 26.3 Ų |
| Viscosity | 4.8cp (25°C) |
| WGK Germany | - |
Sautina N.V, et al. Journal of Molecular Liquids, 2024, 407, 125193.
Isopropyl myristate (IPM) can be utilized to create biocompatible sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/water/IPM systems, which are ideal for preparing reverse microemulsions. AOT, with a hydrophilic-lipophilic balance (HLB) of 10.5, possesses a unique chemical structure that enables it to form alcohol-free reverse microemulsions in both aqueous and nonaqueous environments without the need for additional co-surfactants.
Understanding the structural phase transitions from microemulsions to liquid crystals is crucial for predicting how drugs can be incorporated and delivered to target cells. Gaining insights into these structural changes is essential for optimizing the conditions required for effective drug delivery.
Preparation of the Reverse Microemulsion:
To study phase transitions, various concentrations of AOT solutions in isopropyl myristate were prepared in stoppered test tubes and maintained at a constant temperature of 60°C in a water bath. Distilled water was then gradually added to each sample under continuous stirring.
The pseudo-ternary phase diagram of the microemulsion (ME) region was constructed by slowly titrating the surfactant-oil mixture with water. The titrated mixture was stirred consistently at room temperature, with the microemulsion region identified by its transparent, low-viscosity, and isotropic properties. All selected samples remained stable for several months, indicating the robustness of the prepared systems.
Zhao C, et al. Acta Pharmaceutica Sinica B, 2016, 6(6), 623-628.
Isopropyl myristate (IPM) is widely recognized for its role as a penetration enhancer in transdermal drug delivery systems. The study evaluates how varying concentrations of IPM influence the performance and efficacy of the drug-in-adhesive transdermal patch containing blonanserin.
Materials and Methods: The transdermal patches were prepared using DURO-TAK® 87-2287 as the pressure-sensitive adhesive (PSA). Each patch contained 5% (w/w) blonanserin, with different concentrations of IPM added to assess its effects. An in vitro release experiment was conducted to determine the release rate of blonanserin. Additionally, the adhesive performance of the patches was evaluated through rolling ball tack and shear-adhesion tests. The glass transition temperature (Tg) and rheological parameters of the PSA were also measured to understand the mechanical effects of IPM.
Results: The in vitro release experiment demonstrated a direct relationship between IPM concentration and the release rate of blonanserin. Higher concentrations of IPM led to an increased drug release, indicating its efficacy as a penetration enhancer. However, the adhesive performance tests revealed a trade-off: as the concentration of IPM increased, both tack and shear-adhesion values decreased. This reduction in adhesive properties was attributed to the plasticization effect of IPM on the PSA, as evidenced by a lower glass transition temperature and a decrease in elastic modulus.
Discussion: IPM's role as a plasticizer is crucial in modulating the mechanical properties of the PSA. By reducing the glass transition temperature, IPM increases the flexibility of the adhesive layer, facilitating enhanced drug release. However, this plasticization also compromises the adhesive strength, leading to lower tack and shear adhesion.
Conclusion: IPM serves as a dual-functioning agent in transdermal drug delivery systems - enhancing drug release while also acting as a plasticizer that affects adhesive properties.
Liu Y, et al. Journal of Drug Delivery Science and Technology, 2020, 59, 101891.
Isopropyl myristate (IPM) has been explored as a solvent in the formulation of insulin-loaded reverse micelles for enhancing transdermal drug delivery. IPM, in combination with lecithin, is effective in forming reverse micelles capable of delivering insulin transdermally. The findings could pave the way for further research into IPM-based transdermal delivery systems for various therapeutic agents.
Methodology:
Reverse micelles were prepared by dissolving lecithin in 10 mL of IPM at 30-40 °C. Insulin, dissolved in an aqueous solution and adjusted to a neutral pH, was then added. The mixture was stirred until a transparent yellow gel was formed, signifying the formation of insulin-loaded reverse micelles.
Findings:
The results indicated a significant impact of lecithin concentration and insulin volume on the viscosity of the reverse micelles. As the viscosity increased, insulin release decreased, highlighting the need to optimize these parameters for effective drug delivery. The optimal formulation demonstrated permeation flux ranging from 6.98 ± 2.85 to 8.95 ± 4.74 μg/cm². When tested in alloxan-induced diabetic rabbits, the optimized reverse micelles gel exhibited a prolonged hypoglycemic effect lasting at least 12 hours post-transdermal administration. The relative bioavailability (RBA) of the transdermal insulin was found to be 136.74% compared to subcutaneous insulin, indicating enhanced absorption through the skin.
What is the CAS number of Isopropyl Myristate?
The CAS number of Isopropyl Myristate is 110-27-0.
What is the molecular weight of Isopropyl Myristate?
The molecular weight of Isopropyl Myristate is 270.5.
What is the molecular formula of Isopropyl Myristate?
The molecular formula of Isopropyl Myristate is C17H34O2.
What are the synonyms of Isopropyl Myristate?
The synonyms of Isopropyl Myristate are 1-Methylethyl tetradecanoate and Propan-2-yl tetradecanoate.
What is the boiling point of Isopropyl Myristate?
The boiling point of Isopropyl Myristate is 193 °C.
What is the melting point of Isopropyl Myristate?
The melting point of Isopropyl Myristate is 3 °C.
What is the purity of Isopropyl Myristate?
The purity of Isopropyl Myristate is 95%+.
What is the density of Isopropyl Myristate at 25 °C?
The density of Isopropyl Myristate at 25 °C is 0.85 g/mL.
What are the typical applications of Isopropyl Myristate?
The typical applications of Isopropyl Myristate include use as a dispersing agent, emulsion stabilizer, lubricant, and plasticizer.
In what physical state is Isopropyl Myristate?
Isopropyl Myristate is in a liquid physical state.
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