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CONTACT US| Catalog Number | ACM56406-3 |
| CAS | 56-40-6 |
| Structure |  |
| Synonyms | Blotting buffer |
| IUPAC Name | 2-Aminoacetic acid |
| Molecular Weight | 75.07 |
| Molecular Formula | C2H5NO2 |
| Canonical SMILES | C(C(=O)O)N |
| InChI | InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) |
| InChI Key | DHMQDGOQFOQNFH-UHFFFAOYSA-N |
| Boiling Point | 233 °C |
| Melting Point | 240 °C(lit.) |
| Flash Point | 176.67 °C |
| Purity | 99% |
| Density | 1.595 g/cm³ |
| Solubility | Soluble in water, slightly soluble in ether |
| Appearance | Solid |
| Application | Amino acid drugs |
| Storage | 2-8 °C |
| Complexity | 42.9 |
| Covalently-Bonded Unit Count | 1 |
| Defined Atom Stereocenter Count | 0 |
| Exact Mass | 75.032028402 |
| Heavy Atom Count | 5 |
| Hydrogen Bond Acceptor Count | 3 |
| Hydrogen Bond Donor Count | 2 |
| Monoisotopic Mass | 75.032028402 |
| Physical State | Powder |
| Rotatable Bond Count | 1 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Storage Conditions | 2-8 °C |
| Topological Polar Surface Area | 63.3 Ų |
Giordano C, et al. Microbiology Spectrum, 2024, 12(8).
Multidrug-resistant (MDR) bacteria pose a significant challenge in treating infections, necessitating innovative approaches. High concentrations of glycine can induce bacterial lysis and morphological changes. This study underscores the potential of glycine as a cost-effective and natural adjuvant in combating MDR bacteria.
Study Objectives:
Investigate glycine's effect on nosocomial pathogens. Determine the minimum inhibitory concentration (MIC) and bacteriostatic or bactericidal nature of glycine on select bacterial isolates. Examine the interaction between glycine and antibiotics (meropenem, cefiderocol, colistin) on MDR bacteria.
Methods and Results:
The study revealed a dose-dependent bactericidal activity of glycine on various MDR bacterial strains. The addition of glycine led to significant morphological changes in bacteria, such as elongation and cell swelling, indicating disruption in cell wall synthesis. Glycine's inhibitory effects on enzymes like LD-carboxypeptidase and L-ala-adding enzyme suggest that it interferes with peptidoglycan synthesis, a crucial component of bacterial cell walls. Moreover, glycine demonstrated a synergistic effect when combined with β-lactam antibiotics, such as meropenem, cefiderocol, and colistin. This combination restored the susceptibility of MDR bacteria to these antibiotics, as evidenced by time-kill assays. Glycine's mechanism of action appears to involve the inhibition of enzymes necessary for cross-linked peptidoglycan synthesis, thus enhancing the efficacy of β-lactams.
Conclusion:
Glycine not only exhibits bactericidal activity but also restores the effectiveness of existing antibiotics, offering a promising strategy to address antibiotic resistance.
Rahmi, et al. South African Journal of Chemical Engineering, 2024, 47, 254-261.
Chitosan can be enhanced by modifying it with glycine and TiO2 to improve its adsorption capabilities. The procedure for preparing a composite membrane combining chitosan, glycine, and TiO2 is as follows:
First, 0.7 g of chitosan is dissolved in 100 mL of 2% acetic acid in a beaker and stirred until fully homogeneous. Next, 0.05 g of glycine is added, and the mixture is stirred continuously for 3 hours. Afterward, 0.25 g of TiO2, pre-dispersed in water, is incorporated into the mixture and stirred again until uniform. Finally, the resulting mixture is poured onto a glass plate and dried in an oven at 40 °C for 48 hours.
What is the PubChem CID of glycine?
PubChem CID 750
What is the molecular formula of glycine?
The molecular formula of glycine is C2H5NO2.
What is the molecular weight of glycine?
The molecular weight of glycine is 75.07 g/mol.
What is the IUPAC name of glycine?
The IUPAC name of glycine is 2-aminoacetic acid.
What is the InChI of glycine?
The InChI of glycine is InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5).
What is the Canonical SMILES of glycine?
The Canonical SMILES of glycine is C(C(=O)O)N.
What is the CAS number of glycine?
The CAS number of glycine is 56-40-6.
What is the European Community (EC) Number of glycine?
The European Community (EC) Number of glycine is 200-272-2.
What is the FEMA Number of glycine?
The FEMA Number of glycine is 3287.
What is the KEGG ID of glycine?
The KEGG ID of glycine is C00037.
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