β-GalNAc-PEG4-Azide

Catalog Number	ACM879004929
CAS	879004-92-9
Description	Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
Synonyms	2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside
Molecular Weight	422.44
Molecular Formula	C16H30N4O9
Canonical SMILES	[N-]=[N+]=NCCOCCOCCOCCO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)NC(C)=O
InChI Key	DWQAFMMYPUXSPI-IBEHDNSVSA-N
Purity	>95% (HPLC)
Application	β-GalNAc-PEG4-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates a single ASGPR ligand with a PEG4 linker and azide group reactive handle ready for conjugation. It can be used as a building block for multivalent compounds to enhance ASGPR binding. Upon binding to ASGPR, β-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. β-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.
Form	Solid
PubChem ID	129115265
Stability	1 Year
Storage Temperature	Store at -20℃

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