Vaccine Lab / Alfa Chemistry
Aluminum Phosphate Adjuvant

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Aluminum Phosphate Adjuvant

Catalog Number ACMA00024748
Description The Aluminum Phosphate Adjuvant is a gel suspension containing sterilized aluminum phosphate. It undergoes bulk sterilization by heating it to 121 degrees Celsius at 2 ATM pressure, and then it is aseptically filled under laminar air flow.
Application Aluminum phosphate adjuvants find applications in various areas, including basic research and development, as well as both small-scale and large-scale production. They are also utilized in the manufacturing of veterinary vaccines.
Notably, aluminum phosphate adjuvants have been tested for their potential use in combination vaccines. In these experiments, protein vaccines that have been adsorbed onto the adjuvant were combined with DNA oligonucleotide vaccines. This technology shows promise, particularly in BALB/c systems, where surface and core antigens of the hepatitis B virus are used.
Content AlPO4 2.0%
Feature Under normal vaccine production conditions, when the pH is maintained between 6 and 8, the aluminum phosphate adjuvant particles carry a negative charge. This makes them highly capable of adsorbing positively charged antigens. For example, at a neutral pH isoelectric point of the protein, the adjuvant readily adsorbs alkaline antigens.
pH 7
Physical State Liquid
Recommended Usage This mixture of 5 to 15 mL and dried aluminum phosphate in doses of 400 to 800 mg.
Storage Conditions Ships at room temperature and should be stored at room temperature. Do not freeze. Stable for 6 months.
Type Adjuvants for protein-based vaccines
Knowledge & Learning Q&A

Aluminum Phosphate Adjuvant: Enhancing Vaccine Efficacy and Safety

Aluminum salt adjuvants have been used safely in vaccines for more than 70 years. Aluminum phosphate adjuvant is one of the most common aluminum adjuvants, which can enhance immunogenicity and improve vaccine design. Get more information on:

  • Overview of Aluminum Phosphate Adjuvant
  • The Role and Mechanism of Aluminum Phosphate Adjuvant
  • In Which Vaccines Has Aluminum Phosphate Adjuvant Been Used?
  • Aluminum Phosphate Safety Issues
  • Improvement of Aluminum Phosphate Vaccine Adjuvant

What are aluminum-based adjuvants commonly used for?

Aluminum-based adjuvants are commonly used in many human vaccines to enhance immune response.

What is the role of the physical adsorption of antigen in vaccine immunogenicity?

The physical adsorption of antigen may play a role in vaccine immunogenicity and is a useful marker of vaccine product quality and consistency.

What physicochemical properties of aluminum phosphate (AlPO4) are important to study?

Particle size and chemical composition are important physicochemical properties of aluminum phosphate (AlPO4) that are important to study.

How long have aluminum salts been safely used in vaccines?

Aluminum salts have been safely used in vaccines for more than 70 years.

What were aluminum salts initially used for in vaccines?

Aluminum salts were initially used in the 1930s, 1940s, and 1950s with diphtheria and tetanus vaccines to strengthen the body's immune response to these vaccines.

What are aluminum-containing adjuvants?

Aluminum-containing adjuvants are vaccine ingredients that have been used in vaccines since the 1930s to help the body build stronger immunity against the germ in the vaccine.

What does previous scientific research show about aluminum exposure from following the recommended vaccine schedule?

Previous scientific research has shown that the amount of aluminum exposure in people who follow the recommended vaccine schedule is low and is not readily absorbed by the body.

How can the vaccine adjuvant be effectively controlled throughout the manufacturing process?

The vaccine adjuvant can be effectively controlled throughout the manufacturing process by monitoring key product attributes such as particle size and chemical composition of aluminum phosphate (AlPO4).

Why is it important to monitor the key product attributes of the vaccine adjuvant?

Monitoring the key product attributes of the vaccine adjuvant is important to ensure product quality and consistency.

Our products and services are for research use only and cannot be used for any clinical purposes.

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