CAS 63-42-3 4-(beta-D-Galactosido)-D-glucose - Vaccine Lab / Alfa Chemistry

4-(beta-D-Galactosido)-D-glucose for the Preparation of Novel Hybrid Nanocomposites AuNPs/Lac/Alg

In situ synthesis of gold nanoparticles on novel nanocomposite lactose/alginate: Recyclable catalysis and colorimetric detection of Fe(III) T. Thu-Trang Ho, et al. Carbohydrate Polymers, 2021, 251, 116998.

4-(beta-D-Galactosido)-D-glucose (lactose) can be used to prepare a novel lactose/alginate (Lac/Alg) composite which can reduce gold ions to AuNPs in situ by ionic gelation mechanism.Lactose plays a crucial role as a reducing agent.AuNPs@Lac/ Alg dispersion can be used as an effective probe for the highly selective detection of Fe³⁺ ions.
The preparation procedure is as follows:
Preparation of Blank Lac/Alg Nanocomposite
The Lac/Alg nanocomposite was prepared using the ionotropic gelation method with Alg/Ca²⁺ gelispheres and lactose molecules. First, calcium acetate solution (14.36 mL, 6.5 mg/mL) was added to sodium alginate solution (40 mL, 7 mg/mL) while stirring at 1200 rpm for 1 hour. After equilibrating overnight, the Alg/Ca²⁺ gelispheres were centrifuged at 3000 rpm for 10 minutes and washed with distilled water to remove impurities. Then, lactose solution (16.06 mL, 1.5 mg/mL) was mixed with the Alg/Ca²⁺ gelispheres and stirred for another hour at the same speed. The resulting Lac/Alg gel was ultrasonicated for 30 minutes and left to stabilize overnight. The mixture was centrifuged again at 3000 rpm for 10 minutes and washed with water to obtain the pure blank Lac/Alg nanocomposite, which was used as a standard sample.
In Situ Synthesis of Gold Nanoparticles on Lac/Alg Nanocomposite
Gold nanoparticles (AuNPs) were synthesized on the Lac/Alg nanocomposite by adding an aqueous solution of AuCl₃ (2.05 mg/mL) to the Lac/Alg gel solution (8 mL, 1.0 g/mL). The mixture was heated to facilitate the reduction process, indicated by a color change and monitored using UV-vis spectroscopy between 200-800 nm. To purify the AuNPs@Lac/Alg nanocomposite, the mixture was centrifuged at 3000 rpm for 10 minutes and washed with distilled water to remove impurities and unconverted metal ions. Finally, the composite was dried in an oven at 90°C overnight and stored for further use.

Catalog Number	ACM63423-1
CAS	63-42-3
Structure
Synonyms	Lactose
IUPAC Name	(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol
Molecular Weight	342.3
Molecular Formula	C12H22O11
Canonical SMILES	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)O)CO)O)O)O)O
InChI	InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11-,12+/m1/s1
InChI Key	GUBGYTABKSRVRQ-DCSYEGIMSA-N
Melting Point	222.8 °C
Purity	98%+
Complexity	382
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	10
Exact Mass	342.11621151
Heavy Atom Count	23
Hydrogen Bond Acceptor Count	11
Hydrogen Bond Donor Count	8
Isomeric SMILES	C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O)CO)O)O)O)O
Monoisotopic Mass	342.11621151
Physical State	Powder
Rotatable Bond Count	4
Topological Polar Surface Area	190 Å²