tri-GalNAc-PEG3-Biotin

Catalog Number	ACMA00049966
Description	The trivalent β-GalNAc Ligand is specific for Asialo Glycoprotein Receptors on hepatocyte cells. β-Alanine-PEG3 acts as linker/spacer between multivalent GalNAc and biotin.
Synonyms	tris-GalNAc-β-Ala-PEG3-Biotin, tri-GalNAc-β-Ala-PEG3-Biotin, (β-GalNAc)3-sp-β-Ala-PEG3-Biotin, (β-D-GalNAc-sp)3-NHC(O)-(CH2)2-NHC(O)-PEG3-NH-Biotin, triantennary β-D-GalNAc-β-Alanine-PEG3-Biotin
Molecular Weight	1916.2
Molecular Formula	C83H146N14O34S
Canonical SMILES	O[C@@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OCCCCC(NCCCNC(CCOCC(NC(CCNC(CCOCCOCCOCCNC(CCCC[C@@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@@H]5O[C@H](CO)[C@H](O)[C@H](O)[C@H]5NC(C)=O)=O)=O)=O)=O)O[C@@H]1CO
InChI Key	GFCCTIAQGWLOHY-PTYDYDFOSA-N
Purity	≥90% (HPLC)
Solubility	Soluble to 50 mM in water
Application	tri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary N-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner.
Form	Solid
Stability	1 Year
Storage Temperature	Store at -20℃

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tri-GalNAc-PEG3-Biotin (ACMA00049966)

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