tri-GalNAc-PEG3-Azide

Catalog Number	ACM2925590710
CAS	2925590-71-0
Description	Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
Molecular Weight	1644.83
Molecular Formula	C70H125N13O31
Canonical SMILES	OC[C@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)O[C@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O)=O
InChI Key	QNGSUVMZQPQMPB-CNCRQLPOSA-N
Purity	≥90% (HPLC)
Solubility	Soluble to 4 mM in water
Application	tri-GalNAc-PEG3-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with a PEG3 linker and azide group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.
Form	Solid
Stability	1 Year
Storage Temperature	Store at -20℃

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tri-GalNAc-PEG3-Azide (2925590-71-0)

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