Paromomycin sulfate

Catalog Number	ACM1263894-1
CAS	1263-89-4
Structure
Description	Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections.
Synonyms	Aminosidine sulfate
Molecular Weight	713.71
Molecular Formula	C23H47N5O18S
Canonical SMILES	N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CO.O=S(O)(O)=O
Purity	0.9991
Appearance	Solid
Storage	4°C, sealed storage, away from moisture In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
IC50&Target	Aminoglycoside; Amebae
Initial Source	Streptomyces rimosus NRRL 2455
Research Areas	Infection
Shipping	Room temperature in continental US; may vary elsewhere.
Solvent&Solubility	In Vitro: H2O : 100 mg/mL (140.11 mM; ultrasonic and warming and heat to 80°C) DMSO : 1 mg/mL (1.40 mM; ultrasonic and warming and heat to 80°C) Ethanol : 1 mg/mL (1.40 mM; Need ultrasonic) In Vivo: 1. Add each solvent one by one: PBS Solubility: 100 mg/mL (140.11 mM); Clear solution; Need ultrasonic
Target	Antibiotic; Parasite; Bacterial

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Paromomycin sulfate (1263-89-4)

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