Neomycin sulfate

Catalog Number	ACM1405103-1
CAS	1405-10-3
Structure
Description	Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis.
Molecular Weight	908.88
Molecular Formula	C23H52N6O25S3
Canonical SMILES	O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4]
Purity	≥98.0%
Appearance	Solid
Storage	4°C, sealed storage, away from moisture In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
IC50&Target	Aminoglycoside
Initial Source	Micromonospora species
Research Areas	Infection
Shipping	Room temperature in continental US; may vary elsewhere.
Solvent&Solubility	In Vitro: H2O : 250 mg/mL (275.06 mM; Need ultrasonic) In Vivo: 1. Add each solvent one by one: PBS Solubility: 50 mg/mL (55.01 mM); Clear solution; Need ultrasonic
Target	Bacterial, Antibiotic, Phospholipase

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Neomycin sulfate (1405-10-3)

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