Catalog Number |
ACM1405103-1 |
CAS |
1405-10-3 |
Structure |
|
Description |
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. |
Molecular Weight |
908.88 |
Molecular Formula |
C23H52N6O25S3 |
Canonical SMILES |
O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4] |
Purity |
≥98.0% |
Appearance |
Solid |
Storage |
4°C, sealed storage, away from moisture In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
IC50&Target |
Aminoglycoside |
Initial Source |
Micromonospora species |
Research Areas |
Infection |
Shipping |
Room temperature in continental US; may vary elsewhere. |
Solvent&Solubility |
In Vitro: H2O : 250 mg/mL (275.06 mM; Need ultrasonic) In Vivo: 1. Add each solvent one by one: PBS Solubility: 50 mg/mL (55.01 mM); Clear solution; Need ultrasonic |
Target |
Bacterial, Antibiotic, Phospholipase |
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