MPLA

Catalog Number	ACM1246298634
CAS	1246298-63-4
Structure
Description	Monophosphoryl Lipid A (Synthetic) The product is a synthetic structural analog of monophosphoryl Lipid A (MPLA) that has been shown to boost the immune system through activation of the toll-like receptor 4 (TLR4) resulting in the production of proinflammatory cytokines and antigen-specific effector CD4+ and memory CD8+ T cells. Also referred to as GLA, this adjuvant has been administered to well over 1000 human subjects without serious adverse events.
Synonyms	PHAD® phosphorylated hexaacyl disaccharide Glycopyranoside Lipid A (GLA)
Molecular Weight	1763.469
Molecular Formula	C96H184N3O22P
Purity	> 99%
Solubility	The solubility in ethanol (as well as other alcohols) and DMSO is limited. Additionally, this species is insoluble in water (aqueous buffers, serum etc.); however, it can be dispersed in an aqueous medium using a suitable emulsifier or detergent. This species is soluble in chloroform (at least up to 50 mg/mL) and chloroform:methanol solvent systems, however gentle heating and sonication may be necessary to aid in dissolution. Dropwise additions of methanol or water may aid dissolution in chloroform at higher concentrations. If using in combination with other lipids, dissolve this lipid separately and then combine dissolved lipids in their respective solvent solutions.
Exact Mass	1762.311
Form	Powder
Hygroscopic	No
Light Sensitive	No
Percent Composition	C 65.38%, H 10.52%, N 2.38% ,O 19.96%, P 1.76
Stability	1 Year
Storage Temperature	-20℃
Type	TLR-4 Agonist

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MPLA (1246298-63-4)

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