Framycetin sulfate

Catalog Number	ACM4146309-1
CAS	4146-30-9
Structure
Description	Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.
Synonyms	Neomycin B sulfate; Fradiomycin B sulfate
Molecular Weight	908.88
Molecular Formula	C23H52N6O25S3
Canonical SMILES	O=S(O)(O)=O.O=S(O)(O)=O.O=S(O)(O)=O.N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CN
Purity	≥98.0%
Appearance	Solid
Storage	Powder: -20°C,3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
IC50&Target	Aminoglycoside
Research Areas	Infection
Shipping	Room temperature in continental US; may vary elsewhere.
Solvent&Solubility	In Vitro: H2O : 250 mg/mL (275.06 mM; Need ultrasonic) In Vivo: 1. Add each solvent one by one: PBS Solubility: 50 mg/mL (55.01 mM); Clear solution; Need ultrasonic
Target	Antibiotic; Bacterial

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Framycetin sulfate (4146-30-9)

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