Framycetin

Catalog Number	ACM119040-1
CAS	119-04-0
Structure
Description	Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.
Synonyms	Neomycin B; Fradiomycin B
Molecular Weight	614.64
Molecular Formula	C23H46N6O13
Canonical SMILES	N[C@@H](C[C@H]1N)[C@@]([C@@H]([C@H]1O)O[C@@](O[C@H](CO)[C@H]2O[C@@]([C@@H]([C@@H](O)[C@@H]3O)N)([H])O[C@H]3CN)([H])[C@@H]2O)([H])O[C@H]([C@@H]([C@@H](O)[C@@H]4O)N)O[C@@H]4CN
Appearance	Liquid
Storage	Solution, -20°C, 2 years
IC50&Target	Aminoglycoside
Research Areas	Infection
Shipping	Room temperature in continental US; may vary elsewhere.
Solvent&Solubility	In Vitro: H2O : 100 mg/mL (162.70 mM; Need ultrasonic) DMSO : 50 mg/mL (81.35 mM; Need ultrasonic) In Vivo: 1. Add each solvent one by one: PBS Solubility: 120 mg/mL (195.24 mM); Clear solution; Need ultrasonic 2. Add each solvent one by one: 10% DMSO, 40% PEG300, 5% Tween-80, 45% saline Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution 3. Add each solvent one by one: 10% DMSO, 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution 4. Add each solvent one by one: 10% DMSO, 90% corn oil Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution
Target	Bacterial; Antibiotic

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Framycetin (119-04-0)

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