DODMA

Catalog Number	ACM104162472-2
CAS	104162-47-2
Structure
Description	1,2-dioleyloxy-3-dimethylaminopropane Cationic lipids such as DODMA are considered non-viral carriers for gene therapy. DODMA is used for the preparation of cationic liposomes or lipid nanoparticles (LNP) needing a neutral or low zeta potential. DODMA is extremely effective at encapsulating nucleic acids due to its ability to temporarily reduce pH.
Synonyms	1,2-Dioleyloxy-3-dimethylamino-propane
IUPAC Name	N,N-dimethyl-2,3-bis[(Z)-octadec-9-enoxy]propan-1-amine
Molecular Weight	620.1
Molecular Formula	C41H81NO2
Canonical SMILES	CCCCCCCC/C=C\CCCCCCCCOCC(CN(C)C)OCCCCCCCC/C=C\CCCCCCCC
InChI	GLGLUQVVDHRLQK-WRBBJXAJSA-N
InChI Key	InChI=1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3/b21-19-,22-20-
Boiling Point	649.7±55.0 °C(Predicted)
Purity	>99%
Density	0.869±0.06 g/cm3(Predicted)
Appearance	Colorless to light yellow liquid
Complexity	573
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	619.63
Form	Powder
Heavy Atom Count	44
Hydrogen Bond Acceptor Count	3
Hydrogen Bond Donor Count	0
Hygroscopic	No
Isomeric SMILES	CCCCCCCC/C=C\CCCCCCCCOCC(CN(C)C)OCCCCCCCC/C=C\CCCCCCCC
Light Sensitive	No
Monoisotopic Mass	619.62673083
Percent Composition	C 79.41% H 13.17% N 2.26% O 5.16%
Physical State	Solid
Rotatable Bond Count	37
Shipping	Ambient temperature
Stability	1 Year
Storage Conditions	-20 °C
Storage Temperature	-20℃
Topological Polar Surface Area	21.7 Ų

Knowledge & Learning Case Study Q&A

Common Cationic Lipids and Their Applications in Vaccines

Messenger RNA (mRNA) vaccines have emerged as a groundbreaking tool in the realm of vaccine development. Unlike traditional vaccines, mRNA vaccines work by introducing genetic material encoding a specific antigen into cells, prompting the cells to produce the antigen themselves. This approach stimulates an immune response as the body identifies the antigen as foreign and generates antibodies to combat it. One of the key benefits of mRNA vaccines is their agility in design and production, allowing for rapid response to emerging threats such as viral outbreaks or mutations. Get more information on:

• Role of mRNA in Vaccine Development
• Importance of Cationic Lipids in mRNA Delivery
• Cationic Lipids in mRNA Vaccine Formulations
• Popular Cationic Lipids from Alfa Chemistry
• Examples of Cationic Lipids Utilized in Vaccines

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DODMA (104162-47-2)

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